3,5-bis(acetoxyacetylamino)-4-chlorobenzonitrile

Names

[ Name ]:
3,5-bis(acetoxyacetylamino)-4-chlorobenzonitrile

[Synonym ]:
Acreozast
Acreozst
Tyb-2285
UNII-84DZ9RW4WK

Biological Activity

[Description]:

Acreozast (TYB-2285) is a histamine release inhibitor. Acreozast inhibits the histamine release primed with IL-3. Acreozast might regulate allergic inflammation in vivo by the suppression of mediator release primed with IL-3[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor

Research Areas >> Inflammation/Immunology

Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[References]

[1]. Watanabe A, et al. Effect of TYB-2285 on antigen-induced histamine release from mouse bone marrow-derived persisting cells (P-cells) primed with interleukin-3-containing conditioned medium (IL3-CM). Gen Pharmacol. 1993 Sep;24(5):1207-11.

Chemical & Physical Properties

[ Density]:
1.43g/cm3

[ Boiling Point ]:
588.3ºC at 760mmHg

[ Molecular Formula ]:
C₁₅H₁₄ClN₃O₆

[ Molecular Weight ]:
367.74100

[ Flash Point ]:
309.6ºC

[ Exact Mass ]:
367.05700

[ PSA ]:
141.57000

[ LogP ]:
2.51388

[ Vapour Pressure ]:
8.03E-14mmHg at 25°C

[ Index of Refraction ]:
1.571

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.