3,5-bis(acetoxyacetylamino)-4-chlorobenzonitrile

Names

[ Name ]:
3,5-bis(acetoxyacetylamino)-4-chlorobenzonitrile

[Synonym ]:
Acreozast
Acreozst
Tyb-2285
UNII-84DZ9RW4WK

Biological Activity

[Description]:

Acreozast (TYB-2285) is a histamine release inhibitor. Acreozast inhibits the histamine release primed with IL-3. Acreozast might regulate allergic inflammation in vivo by the suppression of mediator release primed with IL-3[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor

Research Areas >> Inflammation/Immunology

Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[References]

[1]. Watanabe A, et al. Effect of TYB-2285 on antigen-induced histamine release from mouse bone marrow-derived persisting cells (P-cells) primed with interleukin-3-containing conditioned medium (IL3-CM). Gen Pharmacol. 1993 Sep;24(5):1207-11.

Chemical & Physical Properties

[ Density]:
1.43g/cm3

[ Boiling Point ]:
588.3ºC at 760mmHg

[ Molecular Formula ]:
C₁₅H₁₄ClN₃O₆

[ Molecular Weight ]:
367.74100

[ Flash Point ]:
309.6ºC

[ Exact Mass ]:
367.05700

[ PSA ]:
141.57000

[ LogP ]:
2.51388

[ Vapour Pressure ]:
8.03E-14mmHg at 25°C

[ Index of Refraction ]:
1.571

3,5-bis(acetoxyacetylamino)-4-chlorobenzonitrile

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds