Mefexamide
Names
[ CAS No. ]:
1227-61-8
[ Name ]:
Mefexamide
[Synonym ]:
p-Methoxyphenoxyacetic acid 2-(diethylamino)ethylamide
p-Methoxyphenoxyacetic acid 2-[diethylamino]ethylamide
Mefexamide hydrochloride
4-Methoxy-phenoxyessigsaeure-<2-diethylamino-ethylamid>
N,N-Diethyl-N'-<(4-methoxy-phenoxy)-acetyl>-ethylendiamin
mefexamide
Biological Activity
[Description]:
[Related Catalog]:
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.0586 (rough estimate)
[ Boiling Point ]:
460.4ºC at 760 mmHg
[ Molecular Formula ]:
C15H24N2O3
[ Molecular Weight ]:
280.36
[ Flash Point ]:
232.2ºC
[ PSA ]:
50.80000
[ LogP ]:
2.72490
[ Vapour Pressure ]:
1.17E-08mmHg at 25°C
[ Index of Refraction ]:
1.5800 (estimate)
[ Storage condition ]:
2-8℃
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AB7175000
- CHEMICAL NAME :
- Acetamide, N-(2-(diethylamino)ethyl)-2-(p-methoxyphenoxy)-
- CAS REGISTRY NUMBER :
- 1227-61-8
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C15-H24-N2-O3
- MOLECULAR WEIGHT :
- 280.41
- WISWESSER LINE NOTATION :
- 2N2&2MV1OR DO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1500 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CHTPBA Chimica Therapeutica. (Paris, France) V.1-8, 1965-73. For publisher information, see EJMCA5. Volume(issue)/page/year: 1,444,1966
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 110 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FMXXAJ French Medicament Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Discontinued. Volume(issue)/page/year: #2702M
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 135 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AMPYAT Annales Medico-Psychologiques. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1-Series 11, V.2, 1843-1921; V.80- 1922- Volume(issue)/page/year: 123,141,1965
Safety Information
[ Symbol ]:
GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H300-H310-H330
[ Precautionary Statements ]:
P260-P264-P280-P284-P302 + P350-P310
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ Hazard Codes ]:
T+
[ Risk Phrases ]:
26/27/28
[ Safety Phrases ]:
22-36/37/39-45
[ RIDADR ]:
UN 2811 6.1/PG 1
[ WGK Germany ]:
3
[ RTECS ]:
AB7175000
[ HS Code ]:
2924299090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2924299090
[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Articles
Biull. Eksp. Biol. Med. 94(10) , 48-51, (1982)
[Preliminary pharmacological investigations of six new p-chlorphenoxyacetic acid derivatives (author's transl)].
Ann. Univ. Mariae Curie. Sklodowska. Med. 34 , 259-68, (1979)
[Contribution to biotransformation and analysis of the psychopharmacon mefexamide (author's transl)].
Z. Rechtsmed. 87(1-2) , 117-27, (1981)
After oral administration of a therapeutic dosage (400 mg) Mefexamide (I), six excretion products were detected in human urine and subsequently identified by GC/MS and TLC: in addition to the unchange...