Naltriben mesylate

Names

[ Name ]:
Naltriben mesylate

[Synonym ]:
.naltriben
.17-(cyclopropylmethyl)-6,7-didehydro-3,14
Naltriben mesylate
BYK 191023 dihydrochloride
naltriben mesylate

Biological Activity

[Description]:

Naltriben mesylate is a potent delta-2 receptor-selective antagonist, with Kis are 0.013, 19 and 152 nM for δ, μ and κ receptors respectively. Naltriben mesylate selectively attenuates alcohol intake in rats bred for alcohol preference[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Neuronal Signaling >> Opioid Receptor

[In Vivo]

The hypothermia caused by SNC-80 (35 mg/kg, im) is blocked by a delta2 antagonist, Naltriben (2.5 mg/kg; sc; Sprague-Dawley rats weighing 100-125 g)[2].

[References]

[1]. Krishnan-Sarin S, Portoghese PS, Li TK, Froehlich JC. The delta 2-opioid receptor antagonist naltriben selectively attenuates alcohol intake in rats bred for alcohol preference. Pharmacol Biochem Behav. 1995;52(1):153-159.

[2]. Rawls SM, et al. Brain delta2 opioid receptors mediate SNC-80-evoked hypothermia in rats. Brain Res. 2005;1049(1):61-69.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₂₉NO₇S

[ Molecular Weight ]:
511.59

[ Exact Mass ]:
511.16600

[ PSA ]:
128.82000

[ LogP ]:
4.36020

Precursor & DownStream

Precursor

DownStream

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.