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Naltriben mesylate

Names

[ CAS No. ]:
122517-78-6

[ Name ]:
Naltriben mesylate

[Synonym ]:
.naltriben
.17-(cyclopropylmethyl)-6,7-didehydro-3,14
Naltriben mesylate
BYK 191023 dihydrochloride
naltriben mesylate

Biological Activity

[Description]:

Naltriben mesylate is a potent delta-2 receptor-selective antagonist, with Kis are 0.013, 19 and 152 nM for δ, μ and κ receptors respectively. Naltriben mesylate selectively attenuates alcohol intake in rats bred for alcohol preference[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Neuronal Signaling >> Opioid Receptor

[In Vivo]

The hypothermia caused by SNC-80 (35 mg/kg, im) is blocked by a delta2 antagonist, Naltriben (2.5 mg/kg; sc; Sprague-Dawley rats weighing 100-125 g)[2].

[References]

[1]. Krishnan-Sarin S, Portoghese PS, Li TK, Froehlich JC. The delta 2-opioid receptor antagonist naltriben selectively attenuates alcohol intake in rats bred for alcohol preference. Pharmacol Biochem Behav. 1995;52(1):153-159.

[2]. Rawls SM, et al. Brain delta2 opioid receptors mediate SNC-80-evoked hypothermia in rats. Brain Res. 2005;1049(1):61-69.

Chemical & Physical Properties

[ Molecular Formula ]:
C27H29NO7S

[ Molecular Weight ]:
511.59

[ Exact Mass ]:
511.16600

[ PSA ]:
128.82000

[ LogP ]:
4.36020

Precursor & DownStream

Precursor

DownStream

Related Compounds