122517-78-6

122517-78-6 structure

Name: Naltriben mesylate
Chemical Name: naltriben methanesulfonate
CAS Number: 122517-78-6
Molecular Formula: C₂₇H₂₉NO₇S
Molecular Weight: 511.59
Catalog: Signaling Pathways GPCR/G Protein Opioid Receptor
Create Date: 2016-08-18 18:20:56
Modify Date: 2024-01-10 21:21:59
Naltriben mesylate is a potent delta-2 receptor-selective antagonist, with Kis are 0.013, 19 and 152 nM for δ, μ and κ receptors respectively. Naltriben mesylate selectively attenuates alcohol intake in rats bred for alcohol preference[1][2].

Name	naltriben methanesulfonate
Synonyms	.naltriben .17-(cyclopropylmethyl)-6,7-didehydro-3,14 Naltriben mesylate BYK 191023 dihydrochloride naltriben mesylate

Description	Naltriben mesylate is a potent delta-2 receptor-selective antagonist, with Kis are 0.013, 19 and 152 nM for δ, μ and κ receptors respectively. Naltriben mesylate selectively attenuates alcohol intake in rats bred for alcohol preference[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> Neuronal Signaling >> Opioid Receptor
In Vivo	The hypothermia caused by SNC-80 (35 mg/kg, im) is blocked by a delta2 antagonist, Naltriben (2.5 mg/kg; sc; Sprague-Dawley rats weighing 100-125 g)[2].
References	[1]. Krishnan-Sarin S, Portoghese PS, Li TK, Froehlich JC. The delta 2-opioid receptor antagonist naltriben selectively attenuates alcohol intake in rats bred for alcohol preference. Pharmacol Biochem Behav. 1995;52(1):153-159. [2]. Rawls SM, et al. Brain delta2 opioid receptors mediate SNC-80-evoked hypothermia in rats. Brain Res. 2005;1049(1):61-69.

Precursor 0
DownStream 1
111555-58-9