QL-IX-55

Names

[ Name ]:
QL-IX-55

[Synonym ]:
QL-IX-55
CS-0703
9-(6-aminopyridin-3-yl)-1-(4-fluoro-3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one

Biological Activity

[Description]:

QL-IX-55 is a selective ATP-competitive inhibitor of mTORC1/2 with IC50s of 50/50/10-50 nM for Human mTORC1/Yeast mTORC1/Yeast mTORC2, respectively.

[Related Catalog]:

Signaling Pathways >> PI3K/Akt/mTOR >> mTOR

Research Areas >> Cancer

[References]

[1]. Liu Q, Ren T, Fresques T, Oppliger W, Niles BJ, Hur W, Sabatini DM, Hall MN, Powers T, Gray NS.Selective ATP-competitive inhibitors of TOR suppress rapamycin-insensitive function of TORC2 in Saccharomyces cerevisiae.ACS Chem Biol. 2012 Jun 15;7(6):982-7.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₁₄F₄N₄O

[ Molecular Weight ]:
450.39

[ Exact Mass ]:
450.11000

[ PSA ]:
74.53000

[ LogP ]:
5.27110

Related Compounds

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