QL-X-138

QL-X-138 is a selective and potent BTK/MNK dual kinase inhibitor with IC50 of 8, 107.4, and 26 nM for BTK, MNK1, and MNK2, respectively; exhibits covalent binding to BTK and noncovalent binding to MNK; enhances the antiproliferative efficacies in vitro against a variety of B-cell cancer cell lines, as well as AML and CLL primary patient cells; arrests cell cycle progression and strongly induces apoptosis.

References 1. Wu H, et al. Leukemia. 2016 Jan;30(1):173-81. 2. Wang B, et al. Eur J Med Chem. 2017 Sep 8;137:545-557. View Related Products by Target MNK