1469988-63-3
1469988-63-3 structure
- Name: QL-X-138
- Chemical Name: QL-X-138
- CAS Number: 1469988-63-3
- Molecular Formula: C25H19N5O2
- Molecular Weight: 421.46
- Catalog: Signaling Pathways Anti-infection Influenza Virus
- Create Date: 2020-01-12 02:29:25
- Modify Date: 2024-01-14 05:28:09
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QL-X-138 is a selective and potent BTK/MNK dual kinase inhibitor with IC50 of 8, 107.4, and 26 nM for BTK, MNK1, and MNK2, respectively; exhibits covalent binding to BTK and noncovalent binding to MNK; enhances the antiproliferative efficacies in vitro against a variety of B-cell cancer cell lines, as well as AML and CLL primary patient cells; arrests cell cycle progression and strongly induces apoptosis.
| Name | QL-X-138 |
|---|
| Description | QL-X-138 is a selective and potent BTK/MNK dual kinase inhibitor with IC50 of 8, 107.4, and 26 nM for BTK, MNK1, and MNK2, respectively; exhibits covalent binding to BTK and noncovalent binding to MNK; enhances the antiproliferative efficacies in vitro against a variety of B-cell cancer cell lines, as well as AML and CLL primary patient cells; arrests cell cycle progression and strongly induces apoptosis. |
|---|---|
| References | References 1. Wu H, et al. Leukemia. 2016 Jan;30(1):173-81. 2. Wang B, et al. Eur J Med Chem. 2017 Sep 8;137:545-557. View Related Products by Target MNK |
| Molecular Formula | C25H19N5O2 |
|---|---|
| Molecular Weight | 421.46 |