QL-X-138
Modify Date: 2025-08-26 08:13:36
QL-X-138 structure
|
Common Name | QL-X-138 | ||
|---|---|---|---|---|
| CAS Number | 1469988-63-3 | Molecular Weight | 421.46 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H19N5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of QL-X-138QL-X-138 is a selective and potent BTK/MNK dual kinase inhibitor with IC50 of 8, 107.4, and 26 nM for BTK, MNK1, and MNK2, respectively; exhibits covalent binding to BTK and noncovalent binding to MNK; enhances the antiproliferative efficacies in vitro against a variety of B-cell cancer cell lines, as well as AML and CLL primary patient cells; arrests cell cycle progression and strongly induces apoptosis. |
| Name | QL-X-138 |
|---|
| Description | QL-X-138 is a selective and potent BTK/MNK dual kinase inhibitor with IC50 of 8, 107.4, and 26 nM for BTK, MNK1, and MNK2, respectively; exhibits covalent binding to BTK and noncovalent binding to MNK; enhances the antiproliferative efficacies in vitro against a variety of B-cell cancer cell lines, as well as AML and CLL primary patient cells; arrests cell cycle progression and strongly induces apoptosis. |
|---|---|
| References | References 1. Wu H, et al. Leukemia. 2016 Jan;30(1):173-81. 2. Wang B, et al. Eur J Med Chem. 2017 Sep 8;137:545-557. View Related Products by Target MNK |
| Molecular Formula | C25H19N5O2 |
|---|---|
| Molecular Weight | 421.46 |
| InChIKey | JMVDIGHUQAXWIE-UHFFFAOYSA-N |
| SMILES | C=CC(=O)Nc1cc(-n2c(=O)ccc3cnc4ccc(-c5cn[nH]c5)cc4c32)ccc1C |