S38093 HCl

Names

[ CAS No. ]:
1222097-72-4

[ Name ]:
S38093 HCl

[Synonym ]:
4-[3-(Hexahydrocyclopenta[c]pyrrol-2(1H)-yl)propoxy]benzamide hydrochloride (1:1)
Benzamide, 4-[3-(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)propoxy]-, hydrochloride (1:1)

Biological Activity

[Description]:

S 38093 hydrochloride is a brain-penetrant, orally active antagonist of H3 receptor, with Kis of 8.8, 1.44 and 1.2 µM for rat, mouse and human H3 receptors, respectively.

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[References]

[1]. Guilloux JP, et al. S 38093, a histamine H3 antagonist/inverse agonist, promotes hippocampal neurogenesis and improves context discrimination task in aged mice. Sci Rep. 2017 Feb 20;7:42946.

[2]. Sors A, et al. Mechanistic characterization of S 38093, a novel inverse agonist at histamine H3 receptors. Eur J Pharmacol. 2017 May 15;803:11-23

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₂₅ClN₂O₂

[ Molecular Weight ]:
324.85

[ Exact Mass ]:
324.160461

Related Compounds

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