metolachlor-d6

Names

[ CAS No. ]:
1219803-97-0

[ Name ]:
metolachlor-d6

[Synonym ]:
Acetamide, 2-chloro-N-(2-ethyl-6-methylphenyl)-N-[1-(methoxymethyl-d)ethyl-1,2,2,2-d]-
2-Chloro-N-(2-ethyl-6-methylphenyl)-N-[1-methoxy(H)-2-propanyl]acetamide
2-Chloro-N-(2-ethyl-6-methylphenyl)-N-[1-methoxy(H)propan-2-yl]acetamide

Biological Activity

[Description]:

Metolachlor-d6 is the deuterium labeled Metolachlor[1]. Metolachlor is a pre-emergent selective, chloroacetanilide herbicide for the control of a variety of annual grass and broad leaf weeds in corn and other crops. Metolachlor is a chiral herbicide consisting of four stereoisomers[2][3].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Jingqian Xie, et al. Metolachlor Stereoisomers: Enantioseparation, Identification and Chiral Stability. J Chromatogr A. 2016 Sep 9;1463:42-8.  

[3]. D M Stamper, et al. Biodegradation of the Acetanilide Herbicides Alachlor, Metolachlor, and Propachlor. Crit Rev Microbiol. 199824(1):1-22.  

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
406.8±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C15H16ClD6NO2

[ Molecular Weight ]:
289.831

[ Flash Point ]:
199.8±28.7 °C

[ Exact Mass ]:
289.171570

[ PSA ]:
29.54000

[ LogP ]:
3.00

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.533

[ Storage condition ]:
-20°C

Related Compounds