Terbuthylazine-desethyl-d9

Names

[ CAS No. ]:
1219798-52-3

[ Name ]:
Terbuthylazine-desethyl-d9

[Synonym ]:
6-Chloro-N-[2-(H)methyl(H)-2-propanyl]-1,3,5-triazine-2,4-diamine
1,3,5-Triazine-2,4-diamine, 6-chloro-N-[1,1-di(methyl-d)ethyl-2,2,2-d]-
6-Chloro-N-[2-(H)methyl(H)propan-2-yl]-1,3,5-triazine-2,4-diamine

Biological Activity

[Description]:

Terbuthylazine-desethyl-d9 is the deuterium labeled Terbuthylazine-desethyl[1]. Terbuthylazine-desethyl (Desethylterbuthylazine) is a chloro dealkylated metabolite of Terbuthylazine (a triazine herbicide)[2][3].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Potter TL, et, al. Tillage, cover-crop residue management, and irrigation incorporation impact on fomesafen runoff. J Agric Food Chem. 2011 Jul 27;59(14):7910-5.  

[3]. Navarro S, et, al. Determination of simazine, terbuthylazine, and their dealkylated chlorotriazine metabolites in soil using sonication microextraction and gas chromatography. J AOAC Int. Sep-Oct 200083(5):1239-43.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
386.8±25.0 °C at 760 mmHg

[ Molecular Formula ]:
C7H3D9ClN5

[ Molecular Weight ]:
210.712

[ Flash Point ]:
187.8±23.2 °C

[ Exact Mass ]:
210.134613

[ LogP ]:
1.85

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.614

Related Compounds