N-Desethyl amodiaquine

Names

[ Name ]:
N-Desethyl amodiaquine

[Synonym ]:
N-Desethylamodiaquine
4-[(7-Chloro-4-quinolinyl)aMino]-2-[(ethylaMino)Methyl]phenol
N-de-ethyl amodiaquine
Desethylamodiaquine-[2H5]
4-[(7-Chloro-4-quinolyl)amino]-2-aminomethylphenol
N-Desethylamodiaquine dihydrochloride
desethylamodiaquine

Biological Activity

[Description]:

N-Desethyl amodiaquine is the major biologically active metabolite of Amodiaquine. N-Desethyl amodiaquine is an antiparasitic agent. IC50 values for strains V1/S and 3D7 are 97 nM and 25 nM, respectively[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Parasite

Research Areas >> Infection

[References]

[1]. Sasi P, et al. In vivo and in vitro efficacy of amodiaquine against Plasmodium falciparum in an area of continued use of 4-aminoquinolines in East Africa. J Infect Dis. 2009 Jun 1;199(11):1575-82.

Chemical & Physical Properties

[ Density]:
1.304g/cm3

[ Boiling Point ]:
477.8ºC at 760 mmHg

[ Melting Point ]:
168-174ºC

[ Molecular Formula ]:
C₁₈H₁₈ClN₃O

[ Molecular Weight ]:
327.81

[ Flash Point ]:
242.7ºC

[ Exact Mass ]:
332.14500

[ PSA ]:
57.18000

[ LogP ]:
4.91080

[ Index of Refraction ]:
1.69

N-Desethyl amodiaquine

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds