SRI-41897
Names
[ CAS No. ]:
1208824-23-0
[ Name ]:
SRI-41897
Biological Activity
[Description]:
SRI-41897 is a specific small molecule inhibitor of HIV-1 N-terminal region of NL4-3 Vpu (HIV-1 NL4-3 Vpu) with EC50 of 4.4 uM in the GaLV inhibition assays.SRI-41897 blocks Vpu-mediated modulation of CD4, BST-2/Tetherin and antibody dependent cell-mediated toxicity (ADCC).SRI-41897 rescues CD4 surface expression by 47% on infected TZM-GFP cells, also rescues the expression of CD4 and Tetherin in human peripheral blood mononuclear cells (PBMCs).
[References]
1. Carolyn A Robinson, et al. Viruses. 2022 Apr 15;14(4):817.
Chemical & Physical Properties
[ Molecular Formula ]:
C13H11F2N3O2
[ Molecular Weight ]:
279.247