Indole-3-acetamide-d5

Names

[ CAS No. ]:
1204700-53-7

[ Name ]:
Indole-3-acetamide-d5

[Synonym ]:
Indole-3-acetamide
1H-Indole-3-ethanimidic acid
2-(1H-Indol-3-yl)acetamide
1H-Indole-3-acetamide
3-Indoleacetamide

Biological Activity

[Description]:

Indole-3-acetamide-d5 is the deuterium labeled Indole-3-acetamide[1]. Indole-3-acetamide is a biosynthesis intermediate of indole-3-acetic acid (HY-18569). Indole-3-acetic acid is the most common natural plant growth hormone of the auxin class[2].

[Related Catalog]:

Research Areas >> Others

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Thomas Lehmann, et al. Indole-3-acetamide-dependent auxin biosynthesis: a widely distributed way of indole-3-acetic acid production? Eur J Cell Biol. 2010 Dec;89(12):895-905.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
407.1±47.0 °C at 760 mmHg

[ Molecular Formula ]:
C10H10N2O

[ Molecular Weight ]:
174.199

[ Flash Point ]:
200.0±29.3 °C

[ Exact Mass ]:
174.079315

[ LogP ]:
0.79

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.650

Related Compounds