AS1949490

Names

[ CAS No. ]:
1203680-76-5

[ Name ]:
AS1949490

[Synonym ]:
3-[(4-Chlorophenyl)methoxy]-N-[(1S)-1-phenylethyl]- 2-thiophenecarboxamide AS 1949490

Biological Activity

[Description]:

AS1949490 is a potent and selective SHIP-2 (SH2 domain-containing inositol 5′ phosphatase 2) inhibitor, with an IC50 of 620 nM. AS1949490 activated glucose metabolism via up-regulation of GLUT1 gene in L6 myotubes[1][2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase

Research Areas >> Metabolic Disease

[Target]

IC50: 620 nM (SHIP-2)[1].

[References]

[1]. Suwa A, et al. Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase, SHIP2. Br J Pharmacol. 2009 Oct;158(3):879-87.

[2]. Suwa A, et al. Glucose metabolism activation by SHIP2 inhibitors via up-regulation of GLUT1 gene in L6 myotubes. Eur J Pharmacol. 2010 Sep 10;642(1-3):177-82.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₁₈ClNO₂S

[ Molecular Weight ]:
371.88

[ Exact Mass ]:
371.07500

[ PSA ]:
70.06000

[ LogP ]:
6.04630

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Hazard Codes ]:
Xn

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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