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5-Methyl-2'-C-methyluridine

Names

[ CAS No. ]:
119410-84-3

[ Name ]:
5-Methyl-2'-C-methyluridine

[Synonym ]:
1-((2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
Uridine, 5-methyl-2'-C-methyl-
2'-C-METHYL-5-METHYLURIDINE
5-Methyl-2'-C-methyluridine
5-METHYL-2'-C-METHYL-URIDINE

Biological Activity

[Description]:

2’-β-C-Methyl-5-methyluridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C11H16N2O6

[ Molecular Weight ]:
272.25

[ Exact Mass ]:
272.100830

[ PSA ]:
124.78000

[ LogP ]:
-0.26

[ Index of Refraction ]:
1.597

Related Compounds