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Biotin-PEG3-CH2COOH

Names

[ CAS No. ]:
1189560-96-0

[ Name ]:
Biotin-PEG3-CH2COOH

[Synonym ]:
13-Oxo-17-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-3,6,9-trioxa-12-azaheptadecan-1-oic acid
3,6,9-Trioxa-12-azaheptadecan-1-oic acid, 17-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-13-oxo-
MFCD30749255

Biological Activity

[Description]:

Biotin-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
769.1±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H31N3O7S

[ Molecular Weight ]:
433.520

[ Flash Point ]:
419.0±32.9 °C

[ Exact Mass ]:
433.188263

[ LogP ]:
-1.79

[ Vapour Pressure ]:
0.0±5.7 mmHg at 25°C

[ Index of Refraction ]:
1.523

Related Compounds