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Biotin-PEG3-azide

Names

[ CAS No. ]:
875770-34-6

[ Name ]:
Biotin-PEG3-azide

[Synonym ]:
1H-Thieno[3,4-d]imidazole-4-pentanamide, N-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]hexahydro-2-oxo-, (3aS,4S,6aR)-
Biotin-PEG3-Azide
N-(2-{2-[2-(2-Azidoethoxy)ethoxy]ethoxy}ethyl)-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide

Biological Activity

[Description]:

Biotin-PEG3-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

Biotin-C2-PEG3-azide is a biotin with the azide tag, it can be conjugated to antiviral inhibitors, for example, RYL-634, which shows excellent broad-spectrum inhibition activity against various pathogenic viruses, including hepatitis C virus, dengue virus, Zika virus, chikungunya virus, enterovirus[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Yang Y, et al. Discovery, Optimization, and Target Identification of Novel Potent Broad-Spectrum Antiviral Inhibitors.J Med Chem. 2019 Apr 25;62(8):4056-4073.

Chemical & Physical Properties

[ Melting Point ]:
110 °C

[ Molecular Formula ]:
C18H32N6O5S

[ Molecular Weight ]:
444.549

[ Exact Mass ]:
444.215485

[ PSA ]:
179.95000

[ LogP ]:
-0.93

MSDS

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Safety Information

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds