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1189560-96-0

1189560-96-0 structure
1189560-96-0 structure
  • Name: Biotin-PEG3-CH2COOH
  • Chemical Name: Biotin-PEG3-CH2COOH
  • CAS Number: 1189560-96-0
  • Molecular Formula: C18H31N3O7S
  • Molecular Weight: 433.520
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-11-17 22:14:35
  • Modify Date: 2024-01-03 00:24:30
  • Biotin-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name Biotin-PEG3-CH2COOH
Synonyms 13-Oxo-17-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-3,6,9-trioxa-12-azaheptadecan-1-oic acid
3,6,9-Trioxa-12-azaheptadecan-1-oic acid, 17-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-13-oxo-
MFCD30749255
Description Biotin-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density 1.2±0.1 g/cm3
Boiling Point 769.1±60.0 °C at 760 mmHg
Molecular Formula C18H31N3O7S
Molecular Weight 433.520
Flash Point 419.0±32.9 °C
Exact Mass 433.188263
LogP -1.79
Vapour Pressure 0.0±5.7 mmHg at 25°C
Index of Refraction 1.523