H-Leu-Gly-Gly-OH

Names

[ Name ]:
H-Leu-Gly-Gly-OH

[Synonym ]:
L-Leucylglycylglycine
H-LEU-GLY-GLY-OH
(L)-leucyl-glycylglycine
L-Leucyl-glycyl-glycine,L-leucylglycylglycine
N-(N-L-leucylglycyl)glycine
2-[[2-[[(2S)-2-amino-4-methylpentanoyl]amino]acetyl]amino]acetic acid
N-[(S)-2-Amino-4-methylpentanoyl]-Gly-Gly-OH
Glycine,N-(N-L-leucylglycyl)
EINECS 219-925-8
L-LeucylglycylglycineA.R.
MFCD00065942
L-LEU-GLY-GLY

Biological Activity

[Description]:

(S)-2-(2-(2-Amino-4-methylpentanamido)acetamido)acetic acid is a Glycine (HY-Y0966) derivative[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].

[References]

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

Chemical & Physical Properties

[ Density]:
1.199g/cm3

[ Boiling Point ]:
573.7ºC at 760mmHg

[ Melting Point ]:
-220ºC (dec.)

[ Molecular Formula ]:
C₁₀H₁₉N₃O₄

[ Molecular Weight ]:
245.27600

[ Flash Point ]:
300.8ºC

[ Exact Mass ]:
245.13800

[ PSA ]:
121.52000

[ LogP ]:
0.15890

[ Vapour Pressure ]:
1.17E-14mmHg at 25°C

[ Index of Refraction ]:
1.504

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2924199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor.

Nat. Chem. Biol. 5 , 45-52, (2009)

Transporter-related nutrient sensors, called transceptors, mediate nutrient activation of signaling pathways through the plasma membrane. The mechanism of action of transporting and nontransporting tr...

Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1.

J. Med. Chem. 48 , 4410-9, (2005)

The utilization of the membrane transport protein PEPT1 as a drug delivery system is a promising strategy to enhance the oral bioavailability of drugs. Since very little is known about the substrate b...

Fragmental modeling of hPepT2 and analysis of its binding features by docking studies and pharmacophore mapping.

Bioorg. Med. Chem. 19 , 4544-51, (2011)

Over the last years, considerable progress has been made for the identification and characterization of drug transporters, and several modeling studies have been undertaken to predict their effects on...