H-Leu-Gly-OH

Names

[ CAS No. ]:
686-50-0

[ Name ]:
H-Leu-Gly-OH

[Synonym ]:
(S)-2-(2-Amino-4-methylpentanamido)acetic acid
2-[[(2S)-2-amino-4-methylpentanoyl]amino]acetic acid,hydrate
MFCD00065940
EINECS 211-688-9
H-Leu-Gly-OH

Biological Activity

[Description]:

H-Leu-Gly-OH is a Glycine (HY-Y0966) derivative[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].

[References]

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

Chemical & Physical Properties

[ Melting Point ]:
-245ºC (dec.)

[ Molecular Formula ]:
C₈H₁₆N₂O₃

[ Molecular Weight ]:
188.22400

[ Exact Mass ]:
188.11600

[ PSA ]:
92.42000

[ LogP ]:
0.65180

[ Index of Refraction ]:
86 ° (C=2, H2O)

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2924199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor.

Nat. Chem. Biol. 5 , 45-52, (2009)

Transporter-related nutrient sensors, called transceptors, mediate nutrient activation of signaling pathways through the plasma membrane. The mechanism of action of transporting and nontransporting tr...

Copper(II)- cis, cis-1,3,5-triaminocyclohexane complex-promoted hydrolysis of dipeptides: kinetic, speciation and structural studies.

J. Biol. Inorg. Chem. 7 , 843-851, (2002)

The hydrolysis of glycylglycine (GylGly), glycyl-L-leucine (GlyLeu), L-leucylglycine (LeuGly) and glycyl-DL-serine (GlySer) promoted by a copper(II)- cis, cis-1,3,5-triaminocyclohexane complex [Cu(II)...

Cleavage of L-leucine-containing dipeptides by Clostridium butyricum. Khelifa N, Brik M, Tessedre AC, et al.

Bioorg. Med. Chem. 9 , 109-112, (1999)