sarcosine-methyl-d3

Names

[ Name ]:
sarcosine-methyl-d3

[Synonym ]:
n-Tridecyloxyessigsaeure-methylester
MFCD01075434
N-trideuteriomethyl-glycine
N-Methyl-d3-glycine

Biological Activity

[Description]:

Sarcosine-d3 (N-Methylglycine-d3) is the deuterium labeled Sarcosine. Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Membrane Transporter/Ion Channel >> GlyT

Signaling Pathways >> Neuronal Signaling >> GlyT

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Mei-Yi Lee, et al. Effects of sarcosine and N, N-dimethylglycine on NMDA receptor-mediated excitatory field potentials. J Biomed Sci. 2017; 24: 18.

[3]. Katarzyna Socała, et al. Effects of sarcosine, a glycine transporter type 1 inhibitor, in two mouse seizure models. Pharmacol Rep. Mar-Apr 2010;62(2):392-7.

[4]. Mei-Yi Lee, et al. Effects of sarcosine and N, N-dimethylglycine on NMDA receptor-mediated excitatory field potentials. J Biomed Sci. 2017; 24: 18.

[5]. Katarzyna Socała, et al. Effects of sarcosine, a glycine transporter type 1 inhibitor, in two mouse seizure models. Pharmacol Rep. Mar-Apr 2010;62(2):392-7.

Chemical & Physical Properties

[ Density]:
1.13g/cm3

[ Boiling Point ]:
195.1ºC at 760 mmHg

[ Melting Point ]:
208ºC (dec.)(lit.)

[ Molecular Formula ]:
C₃H₄D₃NO₂

[ Molecular Weight ]:
92.11170

[ Flash Point ]:
71.8ºC

[ Exact Mass ]:
92.06650

[ PSA ]:
49.33000

[ Vapour Pressure ]:
0.184mmHg at 25°C

[ Index of Refraction ]:
1.431

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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