4-(2-Diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazinehexanamidehydrochloride

Names

[ Name ]:
4-(2-Diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazinehexanamidehydrochloride

[Synonym ]:
1-Piperazinehexanamide, 4-[1,1'-biphenyl]-2-yl-N-(1,2,3,4-tetrahydro-1-naphthalenyl)-, hydrochloride (1:1)
6-[4-(Biphenyl-2-yl)piperazin-1-yl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide hydrochloride (1:1)
6-[4-(2-Biphenylyl)-1-piperazinyl]-N-(1,2,3,4-tetrahydro-1-naphthalenyl)hexanamide hydrochloride (1:1)

Biological Activity

[Description]:

LP 12 hydrochloride (compound 21) is a potent and selective 5-HT7 receptor agonist with a Ki of 0.13 nM. LP 12 hydrochloride displays selectivity for 5-HT7 over D2, 5-HT1A and 5-HT2A receptors (Ki values are 224 nM, 60.9 nM and >1000 nM, respectively)[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[Target]

5-HT7 Receptor:0.13 nM (IC50)

5-HT1A Receptor:60.9 nM (IC50)

5-HT2A Receptor:1464 nM (IC50)

[References]

[1]. Marcello Leopoldo, et al. Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. J Med Chem. 2007 Aug 23;50(17):4214-21.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₂H₄₀ClN₃O

[ Molecular Weight ]:
518.133

[ Exact Mass ]:
517.286011