AG 18

Names

[ Name ]:
AG 18

[Synonym ]:
2-[(3,4-dihydroxyphenyl)methylidene]propanedinitrile
(3,4-dihydroxybenzylidene)propanedinitrile
MFCD00133899
(3,4-Dihydroxybenzylidene)malononitrile RG-50810
(3,4-Dihydroxybenzylidene)malononitrile
Propanedinitrile, 2-[(3,4-dihydroxyphenyl)methylene]-
AG 18
AG-18

Biological Activity

[Description]:

Tyrphostin 23 (Tyrphostin A23) is an EGFR inhibitor with an IC50 and Kiof 35 and 11 μM, respectively.

[Related Catalog]:

Research Areas >> Cancer

[Target]

EGFR:35 μM (IC50, Cell Assay)

EGFR:11 μM (Ki)

[In Vitro]

10 μM tyrphostin 23 causes significant inhibition of the cell proliferation caused by 1 nM and 1μM ghrelin[2]. Tyrphostin 23 (T23) is a well-known inhibitor of protein tyrosine kinases and has been considered as potential anti-cancer drug. T23 is reported to acutely stimulate the glycolytic flux in primary cultured astrocytes. Tyrphostin 23 stimulates glycolytic flux in cultured astrocytes. Mitochondrial metabolism of brain astrocytes is accelerated by Tyrphostin 23 exposure[3].

[References]

[1]. Gazit A, et al. Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem. 1989 Oct;32(10):2344-52.

[2]. Nanzer AM, et al. Ghrelin exerts a proliferative effect on a rat pituitary somatotroph cell line via the mitogen-activated protein kinase pathway. Eur J Endocrinol. 2004 Aug;151(2):233-40.

[3]. Hohnholt MC, et al. The tricarboxylic acid cycle activity in cultured primary astrocytes is strongly accelerated by the protein tyrosine kinase inhibitor tyrphostin 23. Neurochem Int. 2017 Jan;102:13-21.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
421.1±45.0 °C at 760 mmHg

[ Melting Point ]:
225ºC

[ Molecular Formula ]:
C₁₀H₆N₂O₂

[ Molecular Weight ]:
186.167

[ Flash Point ]:
208.5±28.7 °C

[ Exact Mass ]:
186.042923

[ PSA ]:
88.04000

[ LogP ]:
0.99

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.697

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
Soluble in DMSO, ethanol, or DMF

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Regulation of store-operated Ca2+ entry in pulmonary artery smooth muscle cells.

Cell Calcium 46(2) , 99-106, (2009)

Store-operated Ca2+ entry (SOCE) is an important mechanism for Ca2+ influx in smooth muscle cells; however the activation and regulation of this influx pathway are incompletely understood. In the pres...

Spatio-temporal cellular dynamics of the Arabidopsis flagellin receptor reveal activation status-dependent endosomal sorting.

Plant Cell 24(10) , 4205-19, (2012)

The activity of surface receptors is location specific, dependent upon the dynamic membrane trafficking network and receptor-mediated endocytosis (RME). Therefore, the spatio-temporal dynamics of RME ...

Swelling-activated K+ efflux and regulatory volume decrease efficiency in human bronchial epithelial cells.

J. Membr. Biol. 214(1) , 33-41, (2006)

This study describes the correlation between cell swelling-induced K+ efflux and volume regulation efficiency evaluated with agents known to modulate ion channel activity and/or intracellular signalin...