Rabeprazole sodium

Names

[ Name ]:
Rabeprazole sodium

[Synonym ]:
natrium-2-({[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methyl}sulfinyl)benzimidazol-1-id
Sodium 2-({[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl}sulfinyl)benzimidazol-1-ide
1H-Benzimidazole, 2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]-, sodium salt (1:1)
RABEPRAZOLE NA
sodium,2-[[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methylsulfinyl]benzimidazol-1-ide
sodium 2-{[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methanesulfinyl}-1H-benzimidazol-1-ide
Pariet
Zechin
Rabonik
sodium 2-({[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methyl}sulfinyl)benzimidazol-1-ide
Rebeprazole sodium
Aciphex
Rabeprazole Sodium Salt
Rabeprazole sodium
2-([4-(3-Methoxypropoxy)-3-methylpyridin-2-yl]methylsulfinyl)-1H-benzo[d]imidazole,Pariprazole
Sodium rabeprazole
Rabeprazole (sodium)

Biological Activity

[Description]:

Rabeprazole sodium(LY307640 sodium) is an antiulcer drug in the class of proton pump inhibitors.Target: Proton PumpRabeprazole belongs to a class of antisecretory compounds (substituted benzimidazole proton-pump inhibitors) that do not exhibit anticholinergic or histamine H2-receptor antagonist properties, but suppress gastric acid secretion by inhibiting the gastric H+/K+ATPase (hydrogen-potassium adenosine triphosphatase) at the secretory surface of the gastric parietal cell. Because this enzyme is regarded as the acid (proton) pump within the parietal cell, rabeprazole has been characterized as a gastric proton-pump inhibitor. Rabeprazole blocks the final step of gastric acid secretion. In gastric parietal cells, rabeprazole is protonated, accumulates, and is transformed to an active sulfenamide. When studied in vitro, rabeprazole is chemically activated at pH 1.2 with a half-life of 78 seconds.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Proton Pump

Research Areas >> Inflammation/Immunology

[References]

[1]. http://www.drugbank.ca/drugs/DB01129

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
0.45~0.55 g/ml

[ Boiling Point ]:
603.9ºC at 760 mmHg

[ Melting Point ]:
140-141ºC dec.

[ Molecular Formula ]:
C₁₈H₂₀N₃NaO₃S

[ Molecular Weight ]:
381.424

[ Flash Point ]:
319.1ºC

[ Exact Mass ]:
381.112305

[ PSA ]:
93.41000

[ LogP ]:
3.48420

[ Storage condition ]:
Hygroscopic, -20°C Freezer, Under Inert Atmosphere

[ Water Solubility ]:
H2O: soluble10mg/mL (clear solution)

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Development of alginate-reinforced chitosan nanoparticles utilizing W/O nanoemulsification/internal crosslinking technique for transdermal delivery of rabeprazole.

Life Sci. 110(1) , 35-43, (2014)

First; to develop rabeprazole (RP)-alginate core coated chitosan nanoparticles (NP) utilizing water in oil (W/O) nanoemulsion technique. Second; formulation of transdermal patches loaded RP-NP that av...

Eradication of Helicobacter pylori according to 23S ribosomal RNA point mutations associated with clarithromycin resistance.

J. Infect. Dis. 208(7) , 1123-30, (2013)

Clarithromycin-resistant Helicobacter pylori is associated with point mutations in the 23S ribosomal RNA (rRNA) gene.A total of 1232 patients participated and were divided into 2 control groups and 1 ...

Increased gap density predicts weakness of the epithelial barrier in vivo by confocal laser endomicroscopy in indomethacin-induced enteropathy. Shi S, Wang H, Gao H, et al.

Dig. Dis. Sci. 59(7) , 1398-405, (2014)

Related Compounds

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