Loreclezole

Names

[ Name ]:
Loreclezole

[Synonym ]:
Sodium phosphate monobasic
Loreclezole
LoreclezoleHCl

Biological Activity

[Description]:

Loreclezole, an antiepileptic compound, is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit containing receptors[1][2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[Target]

GABAA receptor[1].

[References]

[1]. Wingrove PB, et al. The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunit. Proc Natl Acad Sci U S A. 1994 May 10;91(10):4569-73.

[2]. Sanna E, et al. Direct activation of GABAA receptors by loreclezole, an anticonvulsant drug with selectivity for the beta-subunit. Neuropharmacology. 1996;35(12):1753-60.

Chemical & Physical Properties

[ Density]:
1.48g/cm3

[ Boiling Point ]:
418.7ºC at 760mmHg

[ Molecular Formula ]:
C₁₀H₆Cl₃N₃

[ Molecular Weight ]:
274.53

[ Flash Point ]:
207ºC

[ Exact Mass ]:
272.96300

[ PSA ]:
30.71000

[ LogP ]:
3.77930

[ Vapour Pressure ]:
3.23E-07mmHg at 25°C

[ Index of Refraction ]:
1.65

[ Storage condition ]:
2-8℃

Safety Information

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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