6-Keto cholestanol

Names

[ Name ]:
6-Keto cholestanol

[Synonym ]:
MFCD00003572
EINECS 214-640-5
6-ketocholestanol

Biological Activity

[Description]:

6-Ketocholestanol is a recoupler for mitochondria, chromatophores and cytochrome oxidase proteoliposomes. 6-Ketocholestanol increases the membrane dipole potential[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Starkov AA, et al. 6-Ketocholestanol is a recoupler for mitochondria, chromatophores and cytochrome oxidase proteoliposomes. Biochim Biophys Acta. 1997 Jan 16;1318(1-2):159-72.

Chemical & Physical Properties

[ Density]:
1 g/cm3

[ Boiling Point ]:
501.3ºC at 760 mmHg

[ Melting Point ]:
140-142 °C

[ Molecular Formula ]:
C₂₇H₄₆O₂

[ Molecular Weight ]:
402.65300

[ Flash Point ]:
212.4ºC

[ Exact Mass ]:
402.35000

[ PSA ]:
37.30000

[ LogP ]:
6.64760

[ Index of Refraction ]:
1.51

[ Storage condition ]:
-20°C Freezer

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Risk Phrases ]:
R24/25

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

SR4 Uncouples Mitochondrial Oxidative Phosphorylation, Modulates AMP-dependent Kinase (AMPK)-Mammalian Target of Rapamycin (mTOR) Signaling, and Inhibits Proliferation of HepG2 Hepatocarcinoma Cells.

J. Biol. Chem. 290 , 30321-41, (2015)

Mitochondrial oxidative phosphorylation produces most of the energy in aerobic cells by coupling respiration to the production of ATP. Mitochondrial uncouplers, which reduce the proton gradient across...

Probing amphotericin B single channel activity by membrane dipole modifiers.

PLoS ONE 7(1) , e30261, (2012)

The effects of dipole modifiers and their structural analogs on the single channel activity of amphotericin B in sterol-containing planar phosphocholine membranes are studied. It is shown that the add...

Effect of agents modifying the membrane dipole potential on properties of syringomycin E channels.

Langmuir 23(13) , 6889-92, (2007)

We evaluated the effect of agents modifying the membrane dipole potential: phloretin, 6-ketocholestanol and RH 421 on the properties of single channels formed by lipodepsipeptide syringomycin E (SRE) ...

Related Compounds

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