TRANS-1-AMINOCYCLOBUTANE-1,3-DICARBOXYLIC ACID

Names

[ Name ]:
TRANS-1-AMINOCYCLOBUTANE-1,3-DICARBOXYLIC ACID

[Synonym ]:
trans-1-aminocyclobutane-1,3-dicarboxylic acid
cis-2,4-methanoglutamate
1-aminocyclobutyl carboxylic acid methyl ester
1-AMINO-CYCLOBUTANECARBOXYLIC ACID METHYL ESTER
trans-2,4-methanoglutamic acid
methyl 1-amino-cyclobutanecarboxylate

Biological Activity

[Description]:

trans-ACBD (trans-1-Aminocyclobutane-1,3-dicarboxylic acid) is a very potent and selective NMDA receptor agonist that modulates glutamatergic neurotransmission[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[References]

[1]. Dimpfel W, et al. Effects of rasagiline, its metabolite aminoindan and selegiline on glutamate receptor mediated signalling in the rat hippocampus slice in vitro. BMC Pharmacol. 2011 Feb 21;11:2.

Chemical & Physical Properties

[ Density]:
1.568g/cm3

[ Boiling Point ]:
288.1ºC at 760mmHg

[ Molecular Formula ]:
C₆H₉NO₄

[ Molecular Weight ]:
159.14000

[ Flash Point ]:
128ºC

[ Exact Mass ]:
159.05300

[ PSA ]:
100.62000

[ Vapour Pressure ]:
0.000607mmHg at 25°C

[ Index of Refraction ]:
1.587

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GU1690000

CHEMICAL NAME :: 1,3-Cyclobutanedicarboxylic acid, 1-amino-, trans-, hydrate

CAS REGISTRY NUMBER :: 117488-23-0

LAST UPDATED :: 199109

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C6-H9-N-O4.H2-O

MOLECULAR WEIGHT :: 177.18

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 33,2905,1990