Busulfan-D8

Names

[ Name ]:
Busulfan-D8

[Synonym ]:
(H)Butane-1,4-diyl dimethanesulfonate
Busulfan-d8
1,4-Butane-d-diol, dimethanesulfonate
Myleran-d8
Busulphan-d8
d8-butane-1,4-diol-1,4-dimethane sulfonate
Misulban-d8
GT-41-d8
1,4-Butanediol-d8-dimethanesulfonate Esters
(H)-1,4-Butanediyl dimethanesulfonate
Busulfex-d8
CB-2041-d8
d8-butane-1,4-dimesylate

Biological Activity

[Description]:

Busulfan-D8 is a deuterium labeled Busulfan. Busulfan is an alkyl sulfonate that acts as an alkylating antineoplastic agent. Busulfan forms both intra- and interstrand crosslinks on DNA. In mammals, Busulfan causes profound and prolonged reduction in the generation of hematopoietic progenitors without significantly affecting lymphocyte levels or humoral antibody responses.

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA Alkylator/Crosslinker

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
464.0±28.0 °C at 760 mmHg

[ Melting Point ]:
112-114ºC

[ Molecular Formula ]:
C₆H₆D₈O₆S₂

[ Molecular Weight ]:
254.351

[ Flash Point ]:
234.4±24.0 °C

[ Exact Mass ]:
254.073395

[ PSA ]:
103.50000

[ LogP ]:
-0.52

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.471

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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