Aurora A Inhibitor I

Names

[ Name ]:
Aurora A Inhibitor I

[Synonym ]:
Aurora-A Inhibitor I
N-(2-Chlorophenyl)-4-{[2-({4-[2-(4-ethyl-1-piperazinyl)-2-oxoethyl]phenyl}amino)-5-fluoro-4-pyrimidinyl]amino}benzamide
Aurora A inhibitor 1
2,4-Bisanilinopyrimidine,10
Aurora A Inhibitor I
N-(2-chlorophenyl)-4-{[2-({4-[2-(4-ethylpiperazin-1-yl)-2-oxoethyl]phenyl}amino)-5-fluoropyrimidin-4-yl]amino}benzamide
N-(2-Chlorophenyl)-4-[[2-[[4-[2-(4-ethyl-1-piperazinyl)-2-oxoethyl]phenyl]amino]-5-fluoro-4-pyrimidinyl]amino]benzamide
S1451_Selleck
HMS3265K21

Biological Activity

[Description]:

Aurora A inhibitor I is a potent and highly selective Aurora A inhibitor with with an IC50 of 3.4 nM.

[Related Catalog]:

Research Areas >> Cancer

[Target]

Aurora A:3.4 nM (IC50)

Aurora B:3.4 μM (IC50)

[In Vitro]

Aurora A inhibitor I is exceptionally selective Aurora A inhibitors. Aurora A inhibitor I is an useful tool compounds for investigating the cellular role of Aurora A kinases without the complication of also inhibiting Aurora B[1].

[References]

[1]. Aliagas-Martin I, Burdick D, Corson L, Dotson J, Drummond J, Fields C, Huang OW, Hunsaker T, Kleinheinz T, Krueger E, Liang J, Moffat J, Phillips G, Pulk R, Rawson TE, Ultsch M, Walker L, Wiesmann C, Zhang B, Zhu BY, Cochran AG.A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B.J Med Chem. 2009 May 28;52(10):3300-7.

[Related Small Molecules]

Alisertib (MLN8237) | Tozasertib | AT9283 | Barasertib (AZD1152-HQPA) | danusertib | Hesperadin | Reversine | MLN8054 | GSK1070916 | AMG-900 | KW-2449 | TAK-632 | TAK-901 | MK-5108(VX-689) | pf-03814735

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₃₁H₃₁ClFN₇O₂

[ Molecular Weight ]:
588.075

[ Exact Mass ]:
587.221191

[ PSA ]:
102.49000

[ LogP ]:
4.39

[ Appearance of Characters ]:
white to beige

[ Index of Refraction ]:
1.679

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: soluble10mg/mL, clear

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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