Tripolin A

Names

[ Name ]:
Tripolin A

Biological Activity

[Description]:

Tripolin A ((E)-Tripolin A) is a specific non-ATP competitive Aurora A kinase inhibitor, with IC50 values of 1.5 μM and 7 μM for Aurora A and Aurora B, respectively[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Aurora Kinase

Signaling Pathways >> Cell Cycle/DNA Damage >> Aurora Kinase

Research Areas >> Others

[Target]

IC50: 1.5 μM (Aurora A), 7 μM (Aurora A)[1].

[In Vitro]

Tripolin A induces mitotic spindle defects and spindle pole abnormalities[1].

[References]

[1]. Iliana A Kesisova, et al. Tripolin A, a Novel Small-Molecule Inhibitor of Aurora A Kinase, Reveals New Regulation of HURP's Distribution on Microtubules. PLoS One. 2013;8(3):e58485.

Chemical & Physical Properties

[ Melting Point ]:
265℃ (decomposition)

[ Molecular Formula ]:
C₁₅H₁₁NO₃

[ Molecular Weight ]:
253.25274

Related Compounds

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