Camptothecin-20(S)-O-propionate hydrate

Names

[ CAS No. ]:
1147090-70-7

[ Name ]:
Camptothecin-20(S)-O-propionate hydrate

Biological Activity

[Description]:

Camptothecin-20(S)-O-propionate (Camptothecin-20-O-propionate) hydrate, the C20-propionate ester of CPT, is a highly effective anticancer agent. Camptothecin-20(S)-O-propionate hydrate is a topoisomerase-Ι inhibitor[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase

[References]

[1]. Xing Liu, et al. Correlation between the sensitivity of tumors to treatment with CZ48 and local concentrations of the active metabolite CPT within the tumors. Biomed Rep. 2013 Mar;1(2):202-206.  

[2]. Zhisong Cao, et al. Crystalline camptothecin-20(S)-O-propionate hydrate: a novel anticancer agent with strong activity against 19 human tumor xenografts. Cancer Res. 2009 Jun 1;69(11):4742-9.  

Chemical & Physical Properties

[ Molecular Formula ]:
C23H26N2O8

[ Molecular Weight ]:
458.46

Related Compounds

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