2-(PHOSPHONOMETHYL)-PENTANEDIOIC ACID

Names

[ Name ]:
2-(PHOSPHONOMETHYL)-PENTANEDIOIC ACID

Biological Activity

[Description]:

PMPA (NMDA antagonist) is an NMDA receptor antagonist with Ki values of 0.84, 2.74, 3.53 and 4.16 μM for NR2A, NR2B, NR2C and NR2D, respectively[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[Target]

Ki: 0.84 μM (NR2A), 2.74 μM (NR2B), 3.53 μM (NR2C), 4.16 μM (NR2D)[1]

[References]

[1]. Feng B, et al. The effect of competitive antagonist chain length on NMDA receptor subunit selectivity. Neuropharmacology. 2005 Mar;48(3):354-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆H₁₃N₂O₅P

[ Molecular Weight ]:
224.15200

[ Exact Mass ]:
224.05600

[ PSA ]:
119.91000

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds

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