Urolithin B

Names

[ Name ]:
Urolithin B

[Synonym ]:
urolithin-B

Biological Activity

[Description]:

Urolithin B is one of the gut microbial metabolites of ellagitannins, and has anti-inflammatory and antioxidant effects. Urolithin B inhibits NF-κB activity by reducing the phosphorylation and degradation of IκBα, and suppresses the phosphorylation of JNK, ERK, and Akt, and enhances the phosphorylation of AMPK. Urolithin B is also a regulator of skeletal muscle mass[1][2].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> AMPK

Signaling Pathways >> PI3K/Akt/mTOR >> Akt

Signaling Pathways >> PI3K/Akt/mTOR >> AMPK

Signaling Pathways >> MAPK/ERK Pathway >> ERK

Signaling Pathways >> MAPK/ERK Pathway >> JNK

Signaling Pathways >> Stem Cell/Wnt >> ERK

[References]

[1]. Lee G, et al. Anti-inflammatory and antioxidant mechanisms of urolithin B in activated microglia. Phytomedicine. 2019 Mar 1;55:50-57.

[2]. Rodriguez J, et al. Urolithin B, a newly identified regulator of skeletal muscle mass. J Cachexia Sarcopenia Muscle. 2017 Aug;8(4):583-597.

Chemical & Physical Properties

[ Density]:
1.395g/cm3

[ Boiling Point ]:
432.6ºC at 760 mmHg

[ Molecular Formula ]:
C₁₃H₈O₃

[ Molecular Weight ]:
212.20100

[ Flash Point ]:
196.6ºC

[ Exact Mass ]:
212.04700

[ PSA ]:
50.44000

[ LogP ]:
2.65180

[ Vapour Pressure ]:
4.34E-08mmHg at 25°C

[ Index of Refraction ]:
1.679

MSDS

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Safety Information

[ HS Code ]:
2914400090

Synthetic Route

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Customs

[ HS Code ]: 2914400090

[ Summary ]:
2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%