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RFARKGALRQKNVHEVKN

Names

[ CAS No. ]:
113731-96-7

[ Name ]:
RFARKGALRQKNVHEVKN

[Synonym ]:
protein kinase c selective inhibitor
protein kinase c fragment
protein kinase c fragment 19-36
pkc selective inhibitor protein
rfarkgalrqknvhevkn
pkc selective inhibitor
h2n-rfarkgalrqknvhevkn-oh
pkc 19-36

Biological Activity

[Description]:

Protein Kinase C (19-36) is a pseudosubstrate peptide inhibitor of protein kinase C (PKC), with an IC50 of 0.18 μM. Protein Kinase C (19-36) markedly attenuated vascular hyperproliferation and hypertrophy as well as glucose-induced suppression of natriuretic peptide receptor response[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> PKC
Research Areas >> Others
Signaling Pathways >> TGF-beta/Smad >> PKC

[Target]

IC50: 0.18 μM (protein kinase C)[1].


[References]

[1]. Yasunari K, et al. Possible involvement of phospholipase D and protein kinase C in vascular growth induced by elevated glucose concentration. Hypertension. 1996 Aug;28(2):159-68.

Chemical & Physical Properties

[ Molecular Formula ]:
C93H159N35O24

[ Molecular Weight ]:
2151.48

[ Exact Mass ]:
2150.23000

[ PSA ]:
1017.03000

[ LogP ]:
4.05580

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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