Pioglitazone D4

Names

[ CAS No. ]:
1134163-29-3

[ Name ]:
Pioglitazone D4

[Synonym ]:
5-({4-[2-(5-Ethyl-2-pyridinyl)ethoxy](H)phenyl}methyl)-1,3-thiazolidine-2,4-dione
2,4-Thiazolidinedione, 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl-2,3,5,6-d]methyl]-

Biological Activity

[Description]:

Pioglitazone D4 (U 72107 D4) is a deuterium labeled Pioglitazone. Pioglitazone (U 72107) is a potent and selective PPARγ agonist with high affinity binding to the PPARγ ligand-binding domain with EC50 of 0.93 and 0.99 μM for human and mouse PPARγ, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Apoptosis >> Ferroptosis
Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR
Research Areas >> Metabolic Disease

[References]

[1]. Kuwabara K, et al. A novel selective peroxisome proliferator-activated receptor alpha agonist, 2-methyl-c-5-[4-[5-methyl-2-(4-methylphenyl)-4-oxazolyl]butyl]-1,3-dioxane-r-2-carboxylic acid (NS-220), potently decreases plasma triglyceride and glucose leve

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
575.4±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C19H16D4N2O3S

[ Molecular Weight ]:
360.46300

[ Flash Point ]:
301.8±28.7 °C

[ Exact Mass ]:
360.14500

[ PSA ]:
93.59000

[ LogP ]:
2.94

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.611

Related Compounds