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VU0155069

Names

[ CAS No. ]:
1130067-06-9

[ Name ]:
VU0155069

Biological Activity

[Description]:

VU0155069 (CAY10593), compound 69, is a selective phospholipase D1 (PLD1) inhibitor with an IC50 value of 46 nM in vitro[1]. VU0155069 (CAY10593) strongly inhibits the invasive migration of several cancer cell lines in transwell assays[2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase

[Target]

PLD1:46 nM (IC50)

PLD2:933 nM (IC50)


[References]

[1]. Scott SA, et al. Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat Chem Biol. 2009 Feb;5(2):108-17.

[2]. Lewis JA, et al. Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1916-20.

Chemical & Physical Properties

[ Molecular Formula ]:
C26H27ClN4O2

[ Molecular Weight ]:
462.97100

[ Exact Mass ]:
462.18200

[ PSA ]:
70.13000

[ LogP ]:
4.92040

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds