Tos-PEG2-O-Propargyl
Names
[ CAS No. ]:
1119249-30-7
[ Name ]:
Tos-PEG2-O-Propargyl
[Synonym ]:
2-(2-(prop-2-ynyloxy)ethoxy)ethyl 4-methylbenzenesulfonate
3,6-dioxanon-8-yn-1-yl p-toluenesulfonate
1-O-tosyl-3,6-dioxanon-8-yne
Biological Activity
[Description]:
Tos-PEG2-O-Propargyl is a PEG-based PROTAC linker can be used in the synthesis of Thalidomide-O-PEG2-propargyl (HY-126458)[1].
[Related Catalog]:
[Target]
PEGs
[In Vitro]
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C14H18O5S
[ Molecular Weight ]:
298.35500
[ Exact Mass ]:
298.08700
[ PSA ]:
70.21000
[ LogP ]:
2.44750
Safety Information
[ Hazard Codes ]:
Xi