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Tos-PEG2-Boc

Names

[ CAS No. ]:
1309666-78-1

[ Name ]:
Tos-PEG2-Boc

[Synonym ]:
Propanoic acid, 3-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]-, 1,1-dimethylethyl ester
MFCD22201525
2-Methyl-2-propanyl 3-(2-{[(4-methylphenyl)sulfonyl]oxy}ethoxy)propanoate

Biological Activity

[Description]:

Tos-PEG2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
460.6±30.0 °C at 760 mmHg

[ Molecular Formula ]:
C16H24O6S

[ Molecular Weight ]:
344.423

[ Flash Point ]:
232.3±24.6 °C

[ Exact Mass ]:
344.129364

[ LogP ]:
2.81

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.501

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds