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Demethoxyfumitremorgin C

Names

[ CAS No. ]:
111768-16-2

[ Name ]:
Demethoxyfumitremorgin C

[Synonym ]:
5H,14H-Pyrrolo[1'',2'':4',5']pyrazino[1',2':1,6]pyrido[3,4-b]indole-5,14-dione, 1,2,3,5a,6,11,12,14a-octahydro-12-(2-methyl-1-propen-1-yl)-, (5aS,12S,14aS)-
demethoxyfumitremorgin C
(5aS,12S,14aS)-12-(2-Methyl-1-propen-1-yl)-1,2,3,5a,6,11,12,14a-octahydro-5H,14H-pyrrolo[1'',2'':4',5']pyrazino[1',2':1,6]pyrido[3,4-b]indole-5,14-dione

Biological Activity

[Description]:

Demethoxyfumitremorgin C is a secondary metabolite of the marine fungus, Aspergillus fumigatus. Demethoxyfumitremorgin C induces prostate cancer cell apoptosis. Demethoxyfumitremorgin C activates caspase-3, -8, and -9, leading to PARP/ cleavage[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Apoptosis >> Caspase
Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR

[References]

[1]. Kim YS, et al. Apoptotic effect of demethoxyfumitremorgin C from marine fungus Aspergillus fumigatus on PC3 human prostate cancer cells. Chem Biol Interact. 2017 May 1;269:18-24.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
617.8±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C21H23N3O2

[ Molecular Weight ]:
349.43

[ Flash Point ]:
327.4±31.5 °C

[ Exact Mass ]:
349.179016

[ LogP ]:
1.89

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.692

[ Storage condition ]:
2-8℃

Safety Information

[ Hazard Codes ]:
Xi


Related Compounds

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