CGS 20625

Names

[ Name ]:
CGS 20625

Biological Activity

[Description]:

CGS 20625 is a potent, selective and orally active partial agonist for the central benzodiazepine receptor. CGS 20625 inhibits [3H]-flunitrazepam binding to central benzodiazepine receptors with an IC50 of 1.3 nM. CGS 20625 can be used for the research of pentylenetetrazol-induced seizures[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[Target]

IC50: 1.3 nM ([3H]-flunitrazepam binding to central benzodiazepine receptors)[1]

[References]

[1]. Williams M, et al. CGS 20625, a novel pyrazolopyridine anxiolytic. J Pharmacol Exp Ther. 1989 Jan;248(1):89-96.

Chemical & Physical Properties

[ Density]:
1.246g/cm3

[ Boiling Point ]:
503.8ºC at 760mmHg

[ Molecular Formula ]:
C₁₈H₁₉N₃O₂

[ Molecular Weight ]:
309.36

[ Flash Point ]:
258.5ºC

[ Exact Mass ]:
309.14800

[ PSA ]:
59.91000

[ LogP ]:
2.99130

[ Vapour Pressure ]:
2.82E-10mmHg at 25°C

[ Index of Refraction ]:
1.617

Related Compounds

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