2’-C-β-Methyl-4-deoxyuridine

Names

[ CAS No. ]:
1106032-88-5

[ Name ]:
2’-C-β-Methyl-4-deoxyuridine

[Synonym ]:
2(1H)-Pyrimidinone, 1-(2-C-methyl-β-D-ribofuranosyl)-
1-(2-C-Methyl-β-D-ribofuranosyl)-2(1H)-pyrimidinone

Biological Activity

[Description]:

2’-C-β-Methyl-4-deoxyuridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
479.5±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C10H14N2O5

[ Molecular Weight ]:
242.23

[ Flash Point ]:
243.8±31.5 °C

[ Exact Mass ]:
242.090271

[ LogP ]:
-1.09

[ Vapour Pressure ]:
0.0±2.7 mmHg at 25°C

[ Index of Refraction ]:
1.652

Related Compounds