Imidazo[4,5-d][1,3]diazepin-8-ol,3,4,7,8-tetrahydro-3-b-D-ribofuranosyl-, (8R)-

Names

[ Name ]:
Imidazo[4,5-d][1,3]diazepin-8-ol,3,4,7,8-tetrahydro-3-b-D-ribofuranosyl-, (8R)-

[Synonym ]:
Coformycin

Biological Activity

[Description]:

Coformycin, a nucleoside antibiotic, is a potent inhibitor of adenosine deaminase (ADA) from Streptomyces species. Coformycin possesses anti-tumor and anti-bacterial activity[1][2].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Metabolic Enzyme/Protease >> Adenosine Deaminase

Signaling Pathways >> Anti-infection >> Bacterial

[In Vivo]

Coformycin (0.2 mg/kg, ip daily) inhibits adenosine deaminase activity for various tissues, including brain, heart, kidney, liver, etc[2]. Animal Model: Swiss-Webster mice[2]. Dosage: 0.2 mg/kg. Administration: IP daily. Result: Inhibited adenosine deaminase activity for various tissues.

[References]

[1]. Coformycin.

[2]. Lukey T, et al. S-adenosylhomocysteine hydrolase activity, deoxyadenosine triphosphate accumulation, and competence of thymocyte and spleen leucocyte response to mitogens in coformycin-treated mice. Biochem Pharmacol. 1983 Apr 15;32(8):1399-406.

Chemical & Physical Properties

[ Density]:
1.96g/cm3

[ Boiling Point ]:
692.7ºC at 760mmHg

[ Molecular Formula ]:
C₁₁H₁₆N₄O₅

[ Molecular Weight ]:
284.26900

[ Flash Point ]:
372.7ºC

[ Exact Mass ]:
284.11200

[ PSA ]:
132.36000

[ Vapour Pressure ]:
3.84E-20mmHg at 25°C

[ Index of Refraction ]:
1.828

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI2931500

CHEMICAL NAME :: Imidazo(4,5-d)(1,3)diazepin-8-ol, 3,4,7,8-tetrahydro-3-beta-D-ribofuranosyl-, (R)-

CAS REGISTRY NUMBER :: 11033-22-0

LAST UPDATED :: 198311

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C11-H16-N4-O5

MOLECULAR WEIGHT :: 284.31

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 35 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,330,1981

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.