Isopentyl nitrite
Names
[ CAS No. ]:
110-46-3
[ Name ]:
Isopentyl nitrite
[Synonym ]:
Amyl Nitrite
Isoamyl nitrite,stabilized
ISO-PENTYLNITRITE
3-METHYLBUTYLNITRIT
ISOAMYL NITRITE/ AMYL NITRITE/ISOPENTYL NITRITE/3-METHYLBUTYL NITRITE/ NITROUS ACID 3-METHYLBUTYL ESTER
Isopentyl nitrite
Nitrous acid, 3-methylbutyl ester
ISOAMYLNITRIT
ISOAMYL NITRITE (100 ML )
Nitramyl
isopentanol nitrite
Isoamylnitrite
Nitrous acid 3-methylbutyl ester
ISOAMYNITRILE
pentyl nitrite
nitrous acid isopentyl ester
Iso-Amyl Nitrite
isopentyl alcohol nitrite
ISOPENTYLNITRITE =3-METHYLBUTYLNITRITE
EINECS 203-770-8
3-Methylbutyl nitrite
Isoamyl Nitrite
ISOPENTYL NITRITE / ISOAMYL NITRITE
MFCD00002057
Chemical & Physical Properties
[ Density]:
1.0±0.1 g/cm3
[ Boiling Point ]:
99.1±9.0 °C at 760 mmHg
[ Molecular Formula ]:
C5H11NO2
[ Molecular Weight ]:
117.146
[ Flash Point ]:
10.0±0.0 °C
[ Exact Mass ]:
117.078979
[ PSA ]:
38.66000
[ LogP ]:
2.45
[ Vapour Pressure ]:
44.6±0.2 mmHg at 25°C
[ Index of Refraction ]:
1.425
[ Stability ]:
Stability Unstable. Air and light sensitive. Flammable. Forms explosive mixtures with air or oxygen. Incompatible with oxidizing agents, reducing agents.
[ Water Solubility ]:
<0.01 g/100 mL at 18 ºC
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- NT0187500
- CHEMICAL NAME :
- Isopentyl alcohol, nitrite
- CAS REGISTRY NUMBER :
- 110-46-3
- BEILSTEIN REFERENCE NO. :
- 0969510
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 12
- MOLECULAR FORMULA :
- C5-H11-N-O2
- MOLECULAR WEIGHT :
- 117.17
- WISWESSER LINE NOTATION :
- ONO2Y
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 505 mg/kg
- TOXIC EFFECTS :
- Behavioral - general anesthetic
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 716 ppm/4H
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - excitement Lungs, Thorax, or Respiration - cyanosis
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1430 ppm/30M
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 130 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 51 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 167 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 16 mg/L
- REFERENCE :
- EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83996 No. of Facilities: 33 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 33 (estimated)
Safety Information
[ Symbol ]:
GHS02, GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H225-H302-H331
[ Precautionary Statements ]:
P210-P261-P311
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
F:Flammable
[ Risk Phrases ]:
R11;R20/22
[ Safety Phrases ]:
S16-S24-S46
[ RIDADR ]:
UN 1113 3/PG 2
[ WGK Germany ]:
1
[ RTECS ]:
NT0187500
[ Packaging Group ]:
II
[ Hazard Class ]:
3
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Cancer Sci. 106(2) , 194-200, (2015)
Autophagy is one of the major causes of drug resistance. For example, the angiogenesis inhibitor bevacizumab shows only transient and short-term therapeutic effects, whereas long-term therapeutic bene...
Tuning of poly-S-nitrosated human serum albumin as superior antitumor nanomedicine.J. Pharm. Sci. 103(7) , 2184-8, (2014)
Macromolecules have been developed as carriers of low-molecular-weight drugs in drug delivery systems (DDS) to improve their pharmacokinetic profile or to promote their uptake in tumor tissue via enha...
Molecular mechanisms of nitrovasodilator bioactivation.Basic Res. Cardiol. 86 , 37-50, (1991)
All nitrovasodilators act intracellularly by a common molecular mechanism. This is characterized by the release of nitric oxide (NO). They are, thus, prodrugs or carriers of the active principle NO, r...