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BIX 02188

Names

[ CAS No. ]:
1094614-84-2

[ Name ]:
BIX 02188

[Synonym ]:
(3Z)-3-[({3-[(Dimethylamino)methyl]phenyl}amino)(phenyl)methylene]-2-oxo-6-indolinecarboxamide
1H-Indole-6-carboxamide, 3-[[[3-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-, (3Z)-
3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indole-6-carboxamide
bix02188

Biological Activity

[Description]:

(E/Z)-BIX02188 is a MEK5/ERK5 pathway inhibitor. (E/Z)-BIX02188 inhibits the catalytic function of purified MEK5 enzyme.(E/Z)-BIX02188 can be used for the role of MEK5/ERK5 pathway in various biological systems [1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[References]

[1]. Tatake RJ, et al. Identification of pharmacological inhibitors of the MEK5/ERK5 pathway. Biochem Biophys Res Commun. 2008 Dec 5;377(1):120-5.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
615.8±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C25H24N4O2

[ Molecular Weight ]:
412.48

[ Flash Point ]:
326.2±31.5 °C

[ Exact Mass ]:
412.189911

[ PSA ]:
87.46000

[ LogP ]:
2.36

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.688

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds