BIX02189

Names

[ Name ]:
BIX02189

[Synonym ]:
1H-Indole-6-carboxamide, 3-[[[3-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo-, (3Z)-
(3Z)-3-[({3-[(Dimethylamino)methyl]phenyl}amino)(phenyl)methylene]-N,N-dimethyl-2-oxo-6-indolinecarboxamide
BIX02189

Biological Activity

[Description]:

(E/Z)-BIX02189 is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

[Related Catalog]:

Research Areas >> Others

[In Vitro]

BIX 02189 是一种选择性的 MEK5 抑制剂，IC50 为 1.5 nM，也抑制 ERK5 的催化活性，IC50 为 810 nM，而不抑制其密切相关的激酶 MEK1、MEK2、ERK2 和 JNK2。

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
653.4±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₇H₂₈N₄O₂

[ Molecular Weight ]:
440.54

[ Flash Point ]:
349.0±31.5 °C

[ Exact Mass ]:
440.221222

[ PSA ]:
64.68000

[ LogP ]:
2.05

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.659

[ Storage condition ]:
-20℃

Related Compounds

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