gamma-secretase modulator 2

Names

[ Name ]:
gamma-secretase modulator 2

[Synonym ]:
2H-1-Benzopyran-2-carbonitrile,6-fluoro-3,4-dihydro-4-oxo
6-fluoro-3-{4-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1H-1,2,3-triazol-1-yl}-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one
6-fluoro-3,4-dihydro-4-oxo-2H-1-benzopyran-2-carbonitrile
gamma-secretase modulator 2

Biological Activity

[Description]:

gamma-secretase modulator 2 is a potent and selective γ-secretase modulator for treatment of Alzheimer's diseaseIC50 value: Target: γ-secretaseγ-secretase modulator is modulation of the action of γ-secretase so as to Selectively attenuate production of Aβ(1-42) and hence find use in treatment or prevention of diseases associated with deposition of Aβ in the brain. γ-secretase modulator is usful in particular Alzheimer's disease.

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> γ-secretase

Signaling Pathways >> Stem Cell/Wnt >> γ-secretase

Research Areas >> Neurological Disease

[Related Small Molecules]

DAPT (GSI-IX) | RO4929097 | YO-01027 | PF-3084014 | LY-411575 | L-685,458 | MK-0752 | Avagacestat | Semagacestat(LY450139) | Z-Ile-Leu-aldehyde | E 2012 | gamma-secretase modulator 1 | NGP555 | BMS 299897 | gamma-secretase modulator 3

Chemical & Physical Properties

[ Density]:
1.43 g/cm3

[ Boiling Point ]:
729.8ºC at 760 mmHg

[ Molecular Formula ]:
C₂₅H₂₂F₄N₆O₂

[ Molecular Weight ]:
514.47500

[ Flash Point ]:
395.2ºC

[ Exact Mass ]:
514.17400

[ PSA ]:
78.07000

[ LogP ]:
4.73470

[ Storage condition ]:
2-8℃

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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