Renin inhibitor-1

Names

[ Name ]:
Renin inhibitor-1

Biological Activity

[Description]:

Renin inhibitor-1 (compound 26) is a potent and orally active renin inhibitor with IC50s of 0.9, 1.8 nM for rh-renin and hPRA, respectively. Renin inhibitor-1 shows antihypertensive efficacy. Renin inhibitor-1 has the potential for the research of hypertension and cardiovascular/renal diseases[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> Renin

[Target]

IC50: 0.9 nM (rh-renin); 1.8 nM (hPRA)[1]

[In Vivo]

Renin inhibitor-1 (compound 26) (10 mg/kg; p.o.) demonstrates a significantly potent hypotensive effect in tsukuba hypertensive mice[1].

[References]

[1]. Daisuke Iijima, et al. Discovery of Novel 2-Carbamoyl Morpholine Derivatives as Highly Potent and Orally Active Direct Renin Inhibitors. ACS Med. Chem. Lett. 2022, 13, 8, 1351–1357.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₃₀N₄O₄

[ Molecular Weight ]:
414.50

Related Compounds

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