Purine-9-beta-D-(2'-deoxy-2'-fluoro) arabinoriboside

Names

[ Name ]:
Purine-9-beta-D-(2'-deoxy-2'-fluoro) arabinoriboside

[Synonym ]:
MFCD25542492
9-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine
9H-Purine, 9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-

Biological Activity

[Description]:

9-(2’-Deoxy-2’-fluoro-β-D-arabinofuranosyl)-9H-purine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.9±0.1 g/cm3

[ Boiling Point ]:
544.8±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₁FN₄O₃

[ Molecular Weight ]:
254.22

[ Flash Point ]:
283.3±32.9 °C

[ Exact Mass ]:
254.081512

[ LogP ]:
-0.67

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.772