WAY-100635 Maleate

Names

[ Name ]:
WAY-100635 Maleate

[Synonym ]:
Cyclohexanecarboxamide, N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl-, (2Z)-2-butenedioate (1:1)
N-{2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl}-N-(2-pyridinyl)cyclohexanecarboxamide (2Z)-2-butenedioate (1:1)
N-{2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxamide (2Z)-but-2-enedioate (1:1)
Cyclohexanecarboxamide (N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl
WAY100635

Biological Activity

[Description]:

WAY-100635 Maleate is a potent and selective 5-HT1A Receptor antagonist with a pIC50 of 8.87, an apparent pA2 of 9.71.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

Research Areas >> Neurological Disease

[Target]

5-HT1A Receptor:8.87 (pIC50)

5-HT1A Receptor:9.71 (pA2)

[In Vitro]

WAY-100635 Maleate is a potent and, at high concentrations, an insurmountable antagonist of the 5-HT1A receptor agonist action of 5-carboxamidotryptamine, with an apparent pA2 value (at 0.3 nM) of 9.71. WAY-100635 displaces specific binding of the 5-HT1A radioligand, [3H]8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin), to rat hippocampal membranes with a plCIC50 of 8.87[1].

[References]

[1]. Forster EA, et al. A pharmacological profile of the selective silent 5-HT1A receptor antagonist, WAY-100635. Eur J Pharmacol. 1995 Jul 25;281(1):81-8.

[Related Small Molecules]

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₃₈N₄O₆

[ Molecular Weight ]:
538.635

[ Exact Mass ]:
538.279114

[ PSA ]:
123.51000

[ LogP ]:
3.54040

Related Compounds

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